Friday 17 April 2020

Science fiction or Science? : [1] Birth of 100 children to Gandhari


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s       Series title: Science fiction or science ?      serial number: 1


Article Title:  Birth of  100  children to Gandhari

Source reference :Mahabharata Book 1- section 49
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Summary      
King Dritharshtra’s wife Gandhari’s fetus is aborted after a two year pregnancy. Sage Vyasa comes and does the needful to enable the birth of 100 sons and one daughter from out of the aborted matter..
In modern technical terminology, the equivalent of the device used by Vyasa is called “artificial womb”. This technology  is fairly close to maturity and has already been  successfully used on animals in the laboratory
       Description of event  as given in source:
One day Gandhari entertained with respectful attention the great Dwaipayana who came to her abode, exhausted with hunger and fatigue. Gratified with Gandhari's hospitality, the Rishi gave her the boon she asked for, viz., that she should have a hundred sons, each equal unto her lord in strength and accomplishments.
Some time later, Gandhari conceived and she bore the burden in her womb for two long years without being delivered. She was greatly distressed at this. At that stage, information reached her that Kunti had brought forth a son whose splendour was like unto the morning sun. Becoming impatient due to the prolonged period of gestation, and deprived of reason by grief, she struck her womb forcefully, without the knowledge of her husband. Thereupon a hard mass of flesh, from two years' growth, came out of her womb.
When she was about to throw it away, Dwaipayana, learning everything by his spiritual powers, promptly came there, and  beholding that ball of flesh, addressed the daughter of Suvala thus, 'What have you done?' Gandhari, without trying to disguise her feelings, addressed the Rishi and said, 'Having heard that Kunti had brought forth a son like unto Surya in splendour, I struck my womb in grief. O Rishi, You have granted me the boon that I should have a hundred sons, but here is only a ball of flesh for those hundred sons!'
Vyasa then said, 'Daughter of Suvala, yes it is so.. But my words can never be futile. I have not spoken an untruth even in jest. Let a hundred pots full of clarified butter be brought instantly, and let them be placed at a concealed spot. In the meantime, let cool water be sprinkled over this ball of flesh." The illustrious and great Rishi himself, by sprinkling water over that ball of flesh, began to divide it into parts, each about the size of the thumb. And as it was being  divided into parts, the nurse began to take them up and put them one by one into those pots filled with clarified butter that had been placed at a concealed spot  and were watched with care..
While this process was going on, the beautiful and chaste Gandhari, realising the affection that one feels for a daughter, began to think within herself, 'There is no doubt that I shall have a hundred sons, the Muni having said so. It can never be otherwise. But I should be very happy if a daughter were born of me over and above these hundred sons and junior to them all. My husband then may attain to those worlds that the possession of a daughter's sons confers. Then again, the affection the women feel for their sons-in-law is great. If, therefore, I obtain a daughter over and above my hundred sons, then, surrounded by sons and daughter's sons, I may feel supremely blessed. If I have ever practised ascetic austerities, if I have ever given anything in charity, if I have ever performed the homa through Brahamanas, if I have ever gratified my superiors by respectful attentions, then as the fruit of those acts let a daughter be born unto me.'
All this while, that illustrious  Krishna-Dwaipayana himself was dividing the ball of flesh; and counting a full hundred of the parts, he said unto the daughter of Suvala, "Here are your hundred sons. I did not speak  to you what was false. Here, however, is one part in excess of the hundred, intended for giving you a daughter's son. This part shall develop into an amiable and fortunate daughter, as you have desired' Then that great ascetic brought another pot full of clarified butter, and put the part intended for a daughter into it. 
Then,in time, were born a full hundred sons to Dhritarashtra and a daughter also in excess of this hundred from among those pieces of the ball of flesh that had been deposited in those pots. The eldest of these was  Duryodhana . The daughter was named Duhsala.


Observations & questions that arise
·        Gandhari’s conception can be assumed to have been a natural process since  no specific mention is made. No artificial methods like some equivalent of in-vitro fertilization seems to have been involved. Only  abnormality stated is that the pregnancy went on for two years without delivery happening.
·        The foetal matter being aborted can  be directly attributed to the self inflicted beating….
·        There could not have been fertilization of a hundred eggs  during a single pregnancy in the natural course, since a human  woman is not designed to carry and deliver a hundred children  in one shot
·        But how did Vyasa  achieve the creation of  100 male and one female babies  from the aborted matter?
o   This is indicative of knowledge and capability to handle and manipulate the foetal matter at the cell and sub-cell level to a hundred embryos or fetuses capable of growing into full-term babies
·        How did Vyasa  create a specific foetus with sex predetermined as female?
o   This reaffirms the above observation. In fact, it is indicative of  ability to manipulate  at  a much deeper chromosomal level.
·        The environment needed for growth into full-term babies—flow of the necessary nourishment, the exact physical parameters etc--- was provided as per instructions by Vyasa
o   This can be looked at as some form of ‘ artificial womb’. Modern science is now in the process of developing such equipment and is expected to become available in the next few years.
o   See news item on this  in the section below

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News items on Artificial womb development
Date: April 25, 2017
The lambs spent four weeks in the external wombs and seemed to develop normally
 But it’s important not to get ahead of the data, says Alan Flake, fetal surgeon at the Children’s Hospital of Philadelphia and lead author of today’s study. “It’s complete science fiction to think that you can take an embryo and get it through the early developmental process and put it on our machine without the mother being the critical element there,” he says.
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April 25, 2017
http://www.npr.org/sections/health-shots/2017/04/25/525044286/scientists-create-artificial-womb-that-could-help-prematurely-born-babies
Scientists have created an "artificial womb" in the hopes of someday using the device to save babies born extremely prematurely.
So far the device has only been tested on fetal lambs. A study published Tuesday involving eight animals found the device appears effective at enabling very premature fetuses to develop normally for about a month.
"We've been extremely successful in replacing the conditions in the womb in our lamb model," says Alan Flake, a fetal surgeon at Children's Hospital of Philadelphia who led the study published in the journal Nature Communications.
"They've had normal growth. They've had normal lung maturation. They've had normal brain maturation. They've had normal development in every way that we can measure it," Flake says.
Flake says the group hopes to test the device on very premature human babies within three to five years.
"What we tried to do is develop a system that mimics the environment of the womb as closely as possible," Flake says. "It's basically an artificial womb."
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Aug23, 2017

Artificial wombs are coming.

The research remains preliminary, but in April a group of scientists at the Children’s Hospital of Philadelphia announced amazing advances in artificial womb technologies. The authors explained how they had successfully sustained significantly premature lambs for four weeks in an artificial womb they had designed.
This enabled the lambs to develop in a way very similar to lambs that had developed in their mothers’ wombs. Indeed, the oldest lamb — more than a year old at the time the paper was published — appeared to be completely normal.

 The technology is not ready for human use,

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Some notes on the process of development of Foetus

Stages of PREGNANCY

During each normal menstrual cycle, one egg (ovum) is usually released from one of the ovaries, about 14 days after the last menstrual period. Release of the egg is called ovulation. The egg is swept into the funnel-shaped end of one of the fallopian tubes.
At ovulation, the mucus in the cervix becomes more fluid and more elastic, allowing sperm to enter the uterus rapidly. Within 5 minutes, sperm may move from the vagina, through the cervix into the uterus, and to the funnel-shaped end of a fallopian tube—the usual site of fertilization. The cells lining the fallopian tube facilitate fertilization.
If a sperm penetrates the egg, fertilization results. Tiny hairlike cilia lining the fallopian tube propel the fertilized egg (zygote) through the tube toward the uterus. The cells of the zygote divide repeatedly as the zygote moves down the fallopian tube. The zygote enters the uterus in 3 to 5 days.
In the uterus, the cells continue to divide, becoming a hollow ball of cells called a blastocyst.
Development of the Blastocyst

Between 5 and 8 days after fertilization, the blastocyst attaches to the lining of the uterus, usually near the top. This process, called implantation, is completed by day 9 or 10.
The wall of the blastocyst is one cell thick except in one area, where it is three to four cells thick. The inner cells in the thickened area develop into the embryo, and the outer cells burrow into the wall of the uterus and develop into the placenta. The placenta produces several hormones that help maintain the pregnancy. 
Development of the Embryo
The next stage in development is the embryo, which develops within the amniotic sac, under the lining of the uterus on one side. This stage is characterized by the formation of most internal organs and external body structures. Most organs begin to form about 3 weeks after fertilization, which equals 5 weeks of pregnancy (because doctors date pregnancy from the first day of the woman's last menstrual period, which is typically 2 weeks before fertilization). At this time, the embryo elongates, first suggesting a human shape. Shortly thereafter, the area that will become the brain and spinal cord (neural tube) begins to develop. The heart and major blood vessels begin to develop earlier—by about day 16. The heart begins to pump fluid through blood vessels by day 20, and the first red blood cells appear the next day. Blood vessels continue to develop in the embryo and placenta.
Almost all organs are completely formed by about 10 weeks after fertilization (which equals 12 weeks of pregnancy). The exceptions are the brain and spinal cord, which continue to form and develop throughout pregnancy.
Development of the Fetus and Placenta
At the end of the 8th week after fertilization (10 weeks of pregnancy), the embryo is considered a fetus. During this stage, the structures that have already formed grow and develop. The following are markers during pregnancy:
·         By 12 weeks of pregnancy: The fetus fills the entire uterus.
·         By about 14 weeks: The sex can be identified.
·         By about 16 to 20 weeks: Typically, the pregnant woman can feel the fetus moving.
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Wikipedia
In biological terms, however, prenatal development is a continuum, with no clear defining feature distinguishing an embryo from a fetus. The use of the term "fetus" generally implies that an embryo has developed to the point of being recognizable as a human; this is the point usually taken to be the ninth week after fertilization. A fetus is also characterized by the presence of all the major body organs, though they will not yet be fully developed and functional and some not yet situated in their final anatomical location.

Gender Assigned
Gender is determined immediately upon fertilization. The 23rd pair of chromosomes establishes the sex of the baby. The mother's egg contains an X chromosome, while the father's sperm carries either another X or a Y chromosome. An XX combination means your baby is female and an XY combination means your baby is male. This means that the baby's gender is determined before it is even considered a fetus.
Development
Though during the first few weeks of fetal development your baby's internal and external genital structures are the same, the organs will eventually change. Your baby's gonads will either become ovaries or testicles. The phallus will become either a clitoris or a penis, and the genital folds will become either labia or scrotum. This all depends whether or not testosterone is present. Testosterone will be present in embryos with a Y chromosome, and male sex organs will begin to form. If testosterone is not present, female organs will develop, making female the "default sex" for human beings.



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